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Bulletin of Botanical Research ›› 2012, Vol. 32 ›› Issue (3): 360-364.doi: 10.7525/j.issn.1673-5102.2012.03.019

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Tumor Cell Absorption of Folate Conjugated Albumin Nanoparticle and Folate Receptor-related Gene Expression

NIE Si-Ming;ZHANG Zhong-Hua;ZHAO Dong-Mei;ZU Yuan-Gang*   

  1. Key Laboratory of Forest Plant Ecology of Northeast Forestry University,Ministry of Education,Harbin 150040
  • Received:1900-01-01 Revised:1900-01-01 Online:2012-05-20 Published:2012-05-20
  • Contact: ZU Yuan-Gang
  • Supported by:

Abstract: To investigate the effect of folate conjugated albumin nanoparticle on tumoral cell, the folate receptor positive FR(+) SK-OV-3 cell and FR(-) lung A549 cell were used for experiment. By the techniques of cell culture in vitro and semi QRT PCR, SKOV3 cell and A549 cell were treated by folate conjugated albumin nanoparticles in various concentrations for 24 h. Folate conjugated albumin nanoparticles significantly increased the expression of FR1 gene of SKOV3 cell. There was a positive correlation between the concentration of folate conjugated albumin nanoparticle and the expression of FR1 gene. Folate conjugated albumin nanoparticle increased the activity of FOLR1 protein and related gene, which may be one of important endocytosis mechanisms of folate conjugated albumin nanoparticle.

Key words: Folate, folate receptor, tumor cell, gene expression

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