Abstract: Response surface method was used optimize the extraction techniques of magnolol and honokiol from Magnoliae. Solvent/solid ratio, ethanol concentration and extraction time served as independent variables while the total extraction yield of magnolol and honokiol served as the dependent variable. Based on multiple linear regression and binomial expression, central composite design and response surface method were employed to optimize the extracting process, and predicative analysis was conducted. The optimized extraction conditions showed that solvent/solid ratio 60 mL·g^-1, ethanol concentration 72% and extraction time 78 min gave the total extraction yield 2.29%. The optimum process was simple in methodology and reliable in extraction yield.

Key words: magnoliae cortex, magnolol, honokiol, response surface method, extraction technology