Abstract: To improve the water-solubility of Volatile oil and the stability in the preparation process, Volatile oil containing drug was prepared in nanoemulsion form and characterized, the components of Volatile oil were analyzed and the HLB values were determined, the emulsion ratio was determined by prescription screening, and the nanoemulsion Volatile oil type, size distribution, surface potential and stability were characterized. The experiment measured ginger volatile oil accounted for 2.1%, was lignt yellow or yellow liquid with Tween -80 and -80 as the Span surfactants, HLB value was 8, the optimum volume ratio of emulsion was oil, emulsion agent, water=6∶1∶13,Laser particle size analyzer measured an average diameter of 41.4 nm, the surface potential was -10.31±1.51 mv, centrifugal stability constant was 21.83%. Volatile oil obtained by this method showed nanoemulsion stability, good dispersion in water, stability, which can effectively reduce the loss of volatile oil.

Key words: Volatile oil, rhizoma zingiberis, nanoemulsion, preparation, characterization