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Bulletin of Botanical Research ›› 2012, Vol. 32 ›› Issue (3): 369-372.doi: 10.7525/j.issn.1673-5102.2012.03.021

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Preparation and Characterization of Hydroxycamptothecin Nanoparticles using Anti-solvent Ultrasonic Method

WANG Ying;ZU Yuan-Gang*;ZHAO Xiu-Hua   

  1. Key Laboratory of Forest Plant Ecology of Northeast Forestry University,Ministry of Education,Harbin 150040
  • Received:1900-01-01 Revised:1900-01-01 Online:2012-05-20 Published:2012-05-20
  • Contact: ZU Yuan-Gang
  • Supported by:

Abstract: Hydroxycamptothecin (HCPT) primary particles were prepared using anti-solvent ultrasonic method in order to improve the water-solubility, stability and bioavailability in vivo. Various indexes were tested according to the solubility of HCPT in different organic solvents and water. The optimal preparation conditions were obtained with the HCPT-DMSO concentration of 5 mg·mL-1, H2O∶DMSO of 1∶1, titrate speed of 4 mL·min-1 and the mixing time of 10 min. Various characterizations of the obtained HCPT were carried out. The SEM result demonstrated that the particles were uniform with the mean particle size of 746 nm. The HCPT primary particles have smaller particles size and the higher solubility compared with the raw HCPT.

Key words: 10-hydroxycamptothecin(HCPT), nanoparticles, anti-solvent ultrasonic method, characterization

CLC Number: