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Bulletin of Botanical Research ›› 2014, Vol. 34 ›› Issue (4): 567-571.doi: 10.7525/j.issn.1673-5102.2014.04.023

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Preparation and Characterization of Vitexin Nanosuspension Frozen Powder

GUO Dong-Jie;GU Cheng-Bo;*;ZU Yuan-Gang;LI Wang;ZHAO Xiu-Hua;   

  1. 1.Key Laboratory of Forest Plant Ecology,Ministry of Education,Northeast Forestry University,Harbin 150040;2.State Engineering Laboratory of Bio-Resources Eco-Utilization,Harbin 150040
  • Received:1900-01-01 Revised:1900-01-01 Online:2014-07-20 Published:2014-07-20
  • Contact: GU Cheng-Bo
  • Supported by:

Abstract: For improving the water solubility and in vitro dissolution rate of vitexin, we prepared vitexin nanosuspension by recrystallization method combined with high pressure homogenization, and characterized the physiochemicalproperties of vitexin nanosuspension frozen powder and in vitro release behavior. The mean particle size and Zeta potential of vitexin nanosuspension after reconstituting were (135.7±10) nm and (-17.05±1.40) mV, respectively. The morphology of vitexin nanoparticles was spherical in shape by scanning electron microscopy(SEM). By XRD, DSC and FT-IR, the chemical properties of vitexin nanoparticles were unchanged when compared with unprocessed vitexin. The dissolution rate of vitexin nanosuspension frozen powder were significantly enhanced, and in vitro cumulative release from the freeze dried nanosuspension were 4.5 times greater than that of pure drug in 5 min.

Key words: vitexin, nanosuspension, preparation, characterization

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