Complex Network Analysis of Flavonoids Activities of Juglans mandshurica

doi:10.7525/j.issn.1673-5102.2015.06.026

Abstract

Abstract: With the natural flavonoids in Juglans mandshurica, we studied the relation between multi-substances and multi-targets, and predicted their activities. We constructed the interaction network between flavonoids of J.mandshurica and different targets by PharmMapper, which reversed docking flavonoids. By analyzing the network features, we revealed the relationships between molecules and targets. The flavonoids of J.mandshurica possessed broad-spectrum bioactivities. Among them, several molecules correspond to the same kind of disease. Avicularin and Afzelin had potential antitumor activity. Avicularin had potential antibacterial activity. 3-hydroxyflavone, myricetin, avicularin, afzelin, astragalin, myricitrin and quercitrin had potential antiparasite activity. This results could forecast data to further develop the flavonoids of J.mandshurica with instructive significance.

Key words: Juglans mandshurica, flavonoids, molecular simulation, network analysis

CLC Number:

LIU Ju-Zhao；NIE Si-Ming*；JIANG Li-Sha；WANG Xi-Qing. Complex Network Analysis of Flavonoids Activities of Juglans mandshurica[J]. Bulletin of Botanical Research, 2015, 35(6): 957-961.

References

1.吴征镒.中国植物志:第21卷［M］.北京:科学出版社,1979.

2.吉林省中医中药研究所,长白山自然保护区,东北师范大学生物系.长白山植物药志［M］.长春:吉林人民出版社,1982:203-205.

3.赵守训.中药辞海:第3卷［M］.北京：中国医药科技出版社,1997.

4.Kim S H,Lee K S,Son J K,et a1.Cytotoxic compounds Juglans mandshurica［J］.Nat Prod,1998,61(5):643-645.

5.李生正,王楠.BSLB法筛选青龙衣与核桃枝抗肿瘤作用有效部位［J］.西北药学杂志,2000,15(3):114-114.

6.Kong Y,Zhang L,Yang Z,et al.Natural product juglone targets three key enzymes from Helicobacter pylori:inhibition assay with crystal structure characterization［J］.Acta Pharmacologica Sinica,2008,29(7):870-876.

7.Kim S H,Lee K S,Son J K,et al.Cytotoxieeom Pounds from the roots of Juglans mandshriea［J］.J Nat Prod,1998,61(5):643-645.

8.杜旭,李玉文,倪雁,等.中药青核桃镇痛作用研究与展望［J］.中国中药杂志,2000,25(1):7-10.

9.J.B.哈本等［英］.黄酮类化合物［M］.北京：科学出版社,1983:251-293.

10.徐筱杰.中药复方的计算模拟研究［J］.化学进展,1999,11(2):202-204.

11.Lipinski C A,Lombardo F,Dominy B W,et al.Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings［J］.Advanced drug delivery reviews,2012,64:4-17.

12.Liu X,Ouyang S,Yu B,et al.Pharm Mapper server: a web server for potential drug target identification using pharmacophore mapping approach［J］.Nucleic acids research,2010,38(suppl 2):W609-W614.

13.Lee E B,Hyun J E,Moon Y I.Effects of Opuntia ficus-indica var. Saboten stem on Gastric damages in rats［J］.Archives of pharmacal research,2002,25(1):67-70.

14.Verma S,Singh A,Mishra A.Taxifolin inhibits GTP binding in wild Apo and mutant(V12G) Apo forms of Ras:Molecular docking and molecular dynamics simulation study［J］.Journal of Biochemical Technology,2012,3(4):426-430.

15.王刚,杜士明,杨光义,等.槲皮素抗肿瘤的分子机制研究进展［J］.中国医院药学杂志,2011,31(4):322-324.

16.Li C,Liu J X,Zhao L,et al.Capillary zone electrophoresis for separation and analysis of four diarylheptanoids and an αtetralone derivative in the green walnut husks(Juglans regia L.)［J］.Journal of pharmaceutical and biomedical analysis,2008,48(3):749-753.

17.辛奇.细粒棘球绦虫成虫基因表达谱分析及抗包虫药物筛选［D］.兰州：兰州大学,2014.

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