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Bulletin of Botanical Research ›› 2015, Vol. 35 ›› Issue (6): 957-961.doi: 10.7525/j.issn.1673-5102.2015.06.026

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Complex Network Analysis of Flavonoids Activities of Juglans mandshurica

LIU Ju-Zhao;NIE Si-Ming*;JIANG Li-Sha;WANG Xi-Qing   

  1. Key Laboratory of Forest Plant Ecology,Ministry of Education,Northeast Forestry University,Harbin 150040
  • Online:2015-11-20 Published:2016-01-18
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Abstract: With the natural flavonoids in Juglans mandshurica, we studied the relation between multi-substances and multi-targets, and predicted their activities. We constructed the interaction network between flavonoids of J.mandshurica and different targets by PharmMapper, which reversed docking flavonoids. By analyzing the network features, we revealed the relationships between molecules and targets. The flavonoids of J.mandshurica possessed broad-spectrum bioactivities. Among them, several molecules correspond to the same kind of disease. Avicularin and Afzelin had potential antitumor activity. Avicularin had potential antibacterial activity. 3-hydroxyflavone, myricetin, avicularin, afzelin, astragalin, myricitrin and quercitrin had potential antiparasite activity. This results could forecast data to further develop the flavonoids of J.mandshurica with instructive significance.

Key words: Juglans mandshurica, flavonoids, molecular simulation, network analysis

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