欢迎访问《植物研究》杂志官方网站,今天是 分享到:

植物研究 ›› 2009, Vol. 29 ›› Issue (5): 637-640.doi: 10.7525/j.issn.1673-5102.2009.05.024

• 论文 • 上一篇    

异甘草素的合成工艺研究

马永婷1,2;骆浩1,2;李双明1,2;李政楠1,2;付玉杰1,2*   

  1. (1.东北林业大学林业生物制剂教育部工程研究中心,哈尔滨150040) (2.东北林业大学森林植物生态学教育部重点实验室,哈尔滨150040)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2009-09-20 发布日期:2009-09-20
  • 通讯作者: 付玉杰
  • 基金资助:
     

Optimization of Synthesis Process of Isoliquiritigenin

MA Yong-Ting;LUO Hao;LI Shuang-Ming;LI Zheng-Nan;FU Yu-Jie;*   

  1. (1.Engineering Research Center of Forest Biopreparation, Ministry of Education,Northeast Forestry University,Harbin150040) (2.Key Laboratory of Forestry Plant Ecology,Ministry of Education,Northeast Forestry University,Harbin150040)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-09-20 Published:2009-09-20
  • Contact: FU Yu-Jie
  • Supported by:
     

摘要: 以2,4-二羟基苯乙酮和对羟基苯甲醛为原料,通过羟基保护,羟醛缩合及脱保护合成得到了异甘草素。并对其中的关键步骤羟醛缩合反应条件如:催化剂的种类,底物的摩尔比,反应温度,溶剂以及反应时间进行了优化。结果表明,在以Ba(OH)2为催化剂,甲醇为反应溶剂,对羟基苯甲醛和2,4-二羟基苯乙酮的摩尔比为1.8∶1,温度为45℃的条件下,反应12 h,羟醛缩合反应的收率最高(77.9%),且体系较为简单,易于纯化。

关键词: 异甘草素, 合成, 工艺优化

Abstract: Isoliquiritigenin was synthesized with 2,4-Dihydroxyacetophenone and 4Hydroxybenzaldehyde as the starting materials by protecting of hydroxy, Aldol Addition and deprotecting. The reaction conditions of the key step-Aldol Addition, including catalyst, ratio of substrates, temperature, solvent and time were optimized. Results showed that the optimal condition of the key step were as follows: catalyst Ba(OH)2, solvent MeOH, M(4-Hydroxybenzaldehyde):M(2,4-Dihydroxyacetophenone)=1.8∶1, tempetature 45℃, and time 12 h. Under the optimal conditions, the yield of the reaction achieved the highest(77.9%). In addition, the reaction system was simple and easily purified.

Key words: isoliquiritigenin, synthesis, optimization of conditions

中图分类号: