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Bulletin of Botanical Research ›› 2020, Vol. 40 ›› Issue (6): 951-960.doi: 10.7525/j.issn.1673-5102.2020.06.018

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Extraction of Camptothecin and Hydroxyl Camptothecin from Camptothecin Leaves by Micellar Mediation Combined with Ultrasound-Microwave-Assisted Method

Jian-Hang YANG, Xiu-Hua ZHAO()   

  1. College of Chemical Engineering and Resource Utilization,Northeast Forestry University,Harbin 150040
  • Received:2020-04-13 Online:2020-11-20 Published:2020-11-04
  • Contact: Xiu-Hua ZHAO E-mail:xiuhuazhao@nefu.edu.cn
  • About author:YANG Jian-Hang(1993—),male,master,mainly engaged in plant resources high value processing and utilization technology development.
  • Supported by:
    National Key Research and Development Program(2017YFD060070601)


In order to explore a new method to extract camptothecin and hydroxy-camptothecin from camptothecin leaves and make full use of camptothecin resources, the active ingredients of camptothecin and hydroxy-camptothecin from camptothecin leaves were extracted from camptothecin leaves powder as raw material. In this paper, the influence of microwave processing time, solid-liquid ratio, microwave power and the concentration of surfactant on the total extraction rate were investigated respectively, and the optimum extraction conditions were obtained. The results showed that the optimal extraction rate was achieved when the microwave processing time was 10 min 30 sec, the solid-liquid ratio was 1∶60, the microwave power was 850 W, and the concentration of surfactant was 8.5 g·L-1. The total extraction rate was 0.056 4% under the optimal process.

Key words: camptothecin, hydroxyl camptothecin, surfactant, ultrasound-microwave-assisted method

CLC Number: