欢迎访问《植物研究》杂志官方网站,今天是 分享到:

植物研究 ›› 2020, Vol. 40 ›› Issue (2): 314-320.doi: 10.7525/j.issn.1673-5102.2020.02.020

• 研究简报 • 上一篇    

β-环糊精包合红松籽油的制备工艺及生物利用度评价

祖述冲   

  1. 东北林业大学森林植物生态学教育部重点实验室, 哈尔滨 150040
  • 收稿日期:2019-11-20 出版日期:2020-03-05 发布日期:2020-03-06
  • 作者简介:祖述冲(1983-),男,博士研究生,主要从事森林植物资源中目的活性物质生态分离的研究。

Preparation Process and Bioavailability Evaluation of β-cyclodextrin Inclusion Korean Pine Seed Oil

ZU Shu-Chong   

  1. Key Laboratory of Forest Plant Ecology, Ministry of Education, Northeast Forestry University, Harbin 150040
  • Received:2019-11-20 Online:2020-03-05 Published:2020-03-06

摘要: 介绍了单因素法优化红松籽油包合物的制备工艺,在最优条件下制备的红松籽油包合物固化率为70.95%,包合物含油率为26.88%。且对红松籽油和红松籽油包合物脂肪酸组分、粒径、电位和生物利用度进行对比。研究结果表明,包合物中红松籽油的各组分含量与红松籽油中各组分含量无明显差异,其中皮诺敛酸的含量为14%~16%。红松籽油包合物的平均粒径为177.3±2.6 nm,电位为-33.01±1.4 mV。红松籽油包合物组的血药最大浓度(Cmax)是红松籽油组的1.27倍,t1/2a是红松籽油的1.42倍;AUC值是红松籽油1.56倍;平均滞留时间(MRT)是红松籽油的1.04倍。因此,通过本实验说明红松籽油包合物与水溶液形成乳剂,粒径减小,水溶性增大,增加了包合物在体内的t1/2a和平均滞留时间(MRT),提高了皮诺敛酸在体内的吸收。

关键词: 红松籽油, 红松籽油包合物, 皮诺敛酸, 生物利用度

Abstract: The single-factor method was used to optimize the preparation process of the Korean pine seed oil inclusion compound. Under the optimal conditions, the solidification rate of the Korean pine seed oil inclusion compound was 70.95%, and the oil content of the inclusion compound was 26.88%. The fatty acid composition, particle size, potential, and bioavailability of Korean pine seed oil and Korean pine seed oil inclusion complex were compared. There was no significant difference between the contents of each component of the Korean pine seed oil in the inclusion compound and that of the Korean pine seed oil, among which the content of pinolenic acid was in 14% to 16%. The average particle size of the Korean pine seed oil inclusion complex was 177.3±2.6 nm, and the potential was -33.01±1.4 mV. The blood drug concentration(CMAX), t1/2A, AUC and MRT were 1.27, 1.42, 1.56 and 1.04 times of the Korean pine oil inclusion complex group, respectively. The inclusion complex of Korean pine seed oil and aqueous solution formed an emulsion, the particle size decreased, the water solubility increased, the inclusion complex in vivo t1/2A and the average retention time(MRT) increased, and the absorption of pinolenic acid in vivo increased.

Key words: Korean pine seed oil, Korean pine seed oil inclusion compound, pinolenic acid, bioavailability

中图分类号: