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Bulletin of Botanical Research ›› 2009, Vol. 29 ›› Issue (5): 637-640.doi: 10.7525/j.issn.1673-5102.2009.05.024

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Optimization of Synthesis Process of Isoliquiritigenin

MA Yong-Ting;LUO Hao;LI Shuang-Ming;LI Zheng-Nan;FU Yu-Jie;*   

  1. (1.Engineering Research Center of Forest Biopreparation, Ministry of Education,Northeast Forestry University,Harbin150040) (2.Key Laboratory of Forestry Plant Ecology,Ministry of Education,Northeast Forestry University,Harbin150040)
  • Received:1900-01-01 Revised:1900-01-01 Online:2009-09-20 Published:2009-09-20
  • Contact: FU Yu-Jie
  • Supported by:

Abstract: Isoliquiritigenin was synthesized with 2,4-Dihydroxyacetophenone and 4Hydroxybenzaldehyde as the starting materials by protecting of hydroxy, Aldol Addition and deprotecting. The reaction conditions of the key step-Aldol Addition, including catalyst, ratio of substrates, temperature, solvent and time were optimized. Results showed that the optimal condition of the key step were as follows: catalyst Ba(OH)2, solvent MeOH, M(4-Hydroxybenzaldehyde):M(2,4-Dihydroxyacetophenone)=1.8∶1, tempetature 45℃, and time 12 h. Under the optimal conditions, the yield of the reaction achieved the highest(77.9%). In addition, the reaction system was simple and easily purified.

Key words: isoliquiritigenin, synthesis, optimization of conditions

CLC Number: