Abstract: The process conditions for the extraction of salidroside and p-tyrosol from Rhodiola sachalinensis A Bor.was studied by using the comparison of supercritical CO₂ extraction method and ethanol extraction method at normal temperature.The conclusion was as following:the salidroside in Rhodiola sachalinensis raw materials could not be extracted effectively by supercritical CO₂ extraction method, which could only extract 1.2%of the salidroside but could extract 80%of the p-tyrosol in Rhodiola sachalinensis raw materials and the relative content of p-tyrosol in extracting solution could reach 45.68%;the salidroside and p-tyrosol could be extracted effectively at the same time by ethanol extraction method at normal temperature, however, the relative content of both materials in extracting solution was low and it would be difficult for further separation and purification.Our results indicated that effective separation will be realized and industrialization process of active components in Rhodiola sachalinensis will be pushed forward if supercritical CO₂ extractionmethod and ethanol extraction method at normal temperature are combined effectively.

Key words: Rhodiola sachalinensis A Bor., salidroside, P-tyrosol, supercritical CO₂ extraction