Abstract: Several methods on the wall-cracking of Ganoderma lucidum spore were carried on, mainly wall-cracking methods included supercritical wall-breaking, homogenate wall-cracking and ultrasonic wall-breaking. The results showed that adopting supercritical high-pressure steady state wall-cracking method could particularly improve the wall-crushing rate of Ganoderma lucidum spore. Although the wall-cracking rate of homogenate wall-cracking and ultrasonic wall-cracking was lower and most of the spores of Ganoderma lucidum were integrate in the microscope,the contents were nearly disappeared, attach to the purpose extracting effective constituentof spore inner.

Key words: Ganoderma lucidum spore, supercritical high-pressure steady state wall-cracking, homogenate wall-cracking