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Bulletin of Botanical Research ›› 2019, Vol. 39 ›› Issue (3): 450-457.doi: 10.7525/j.issn.1673-5102.2019.03.015

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Antitumor Activity of Artemisinin Microspheres Loaded with Porous Starch

ZHAO Xue, YANG Feng-Jian, ZHONG Chen, ZHANG Yuan-Yuan, GE Yun-Long, DENG Yi-Ping, SUI Guang-Chao   

  1. Northeast Forestry University, Harbin 150040
  • Received:2019-01-30 Online:2019-05-05 Published:2019-05-11
  • Supported by:
    Forestry science and technology project of Heilongjiang province(Xun Ke)(HLJXK01);Study on Anti-tumor and Functional Mechanism of Artemisinin and Its Derivatives(2572016AA37)

Abstract: To investigate the antitumor activity of porous starch loaded artemisinin microspheres(ART-PS) and artemisinin active drugs(ART) at different concentrations, and the growth inhibition of tumor cells after combined with total ferritin, respectively, in the in vitro experiments, human hepatocellular carcinoma cells and normal hepatocytes at logarithmic growth stage were inoculated to 96-well plates at different contents(0, 50, 100, 150 and 200 μmol·L-1). Concentrations determined by MTT, according to the results of equal treatment, porous starch load on tumor cell HepG2 artemisinin microspheres and the inhibition effect of SMMC-7721 were higher than that of artemisinin technical, but compared with doxorubicin hydrochloride, has low cytotoxicity, on the side effects of normal cells HL7702 is very low, the results associated with respectively after full iron transferrin inhibition for the growth of tumor cells. The porous starch loaded artemisinin microspheres had obvious inhibitory effect on the proliferation of human hepatocellular carcinoma cells, the effect was better than the original artemisinin drugs, and the toxic and side effects on normal hepatocytes were very low, it provides an important reference for the application and research of artemisinin in the treatment of cancer.

Key words: artemisinin, holo-transferrin, liver cancer

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