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Bulletin of Botanical Research ›› 2013, Vol. 33 ›› Issue (4): 484-489.doi: 10.7525/j.issn.1673-5102.2013.04.016

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Preparation, Characterization and Evaluation of in vitro Release of Folate-Conjugated Carboplatin and Paclitaxel -loaded Bovine Serum Albumin Tumor-targeting Nanoparticles

SHAN Chang;ZU Yuan-Gang*;ZHAO Xiu-Hua;SANG Mei   

  1. Key Laboratory of Forest Plant Ecology,Northeast Forestry University,Ministry of Education,Harbin 150040
  • Received:1900-01-01 Revised:1900-01-01 Online:2013-07-20 Published:2013-07-20
  • Contact: ZU Yuan-Gang
  • Supported by:

Abstract: Paclitaxel under the trade name Taxol, is a natural compounds isolated and purified from the trees of the Taxus(Taxaceae L.) belonging to taxus(Taxus L.). Paclitaxel and carboplatin are anti-cancer drugs currently with high clinical utility rates, which often used in combination on the clinical treatment of different types of cancer. Coupling folic acid in bovine serum albumin as a drug carrier, surface coating using nano-particle and solvent technology, folate-targeted carboplatin-paclitaxel albumin nanoparticles were prepared, and the in vitro release properties of targeted drug were studied. Research results are as follows: the mean grain size of carboplatin-paclitaxel albumin nanoparticles was 199.4 nm, the zeta electric potential was -30.90 mV; the envelope rates were 91.4% for carboplatin and 56.1% for paclitaxel, respectively; the drug loading capacity was 21%. It was proven that within 12 h a good stability was maintained through the reconstitution of the fa-carboplatin-paclitaxel albumin nanoparticles. In addition, the folic acid-carboplatin-paclitaxel albumin nanoparticles showed an evident slow-release effect as compared with the carboplatin and paclitaxel original powder, the in vitro release time was up to 120 h.

Key words: folic acid, carboplatin, paclitaxel, bovine serum albumin, target, desolvation

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